CP-866087 - An Overview

If an individual has overdosed and it has severe signs or symptoms like passing out or issues respiratory, phone 911. Normally, connect with a poison control center without delay.

Acute progress or exacerbation of congestive coronary heart failure and new onset of decreased left ventricular ejection fraction have transpired

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There have already been experiences of life-threatening graft versus host disease in patients with myeloma acquiring treatment method with bortezomib. Consequently, all people with various myeloma and lymphoma should really obtain irradiated blood goods to reduce this risk.

Contraindicated (one)bortezomib will increase amounts of eliglustat by impacting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with powerful or reasonable CYP2D6 inhibitors, minimize eliglustat dose from eighty four mg BID to eighty four mg the moment everyday in in depth and intermediate metabolizers; eliglustat is contraindiated if Bortezomib potent or average CYP2D6 inhibitors are presented concomitantly CDK4/6-IN-6 with powerful or reasonable CYP3A inhibitors.

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Patients with pre-present significant neuropathy needs to be treated with bortezomib only after watchful chance-advantage evaluation

Limit foods and nutritional supplements large in vitamin C. Vitamin C may perhaps interfere With all the therapeutic action of this drug. Foods substantial in vitamin C include citrus fruits and beverages.

bortezomib will increase the amount or effect of ruxolitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

bortezomib will lessen the level or influence of pantoprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

cyclophosphamide will enhance the level or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.

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mitotane decreases levels of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a Dup 747 robust inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for doable dosage adjustments.

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